![]() ![]() Protein folding problem: Is it possible to predict the secondary, tertiary and quaternary structure of a polypeptide sequence based solely on the sequence and environmental information? Inverse protein-folding problem: Is it possible to design a polypeptide sequence which will adopt a given structure under certain environmental conditions? See Protein folding.What is the origin of homochirality in amino acids and sugars? See Homochirality.Better-than perfect enzymes: Why do some enzymes exhibit faster-than-diffusion kinetics? See Enzyme kinetics.Nucleophiles with an electronegative atom and one or more lone pairs adjacent to the nucleophilic center are particularly reactive. What is the origin of the alpha effect?.What is the origin of the bond rotation barrier in ethane, steric hindrance or hyperconjugation? See Bond rotation barrier.On-water reactions: Why are some organic reactions accelerated at the water-organic interface? See On-water reactions.Solvolysis of the norbornyl cation: Why is the norbornyl cation so stable? Is it symmetrical? This problem has been largely settled for the unsubstituted norbornyl cation, but not for the substituted cation.
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